Erythromycin has a range of activity similar to penicillin but it differs in being predominantly bacteriostatic. Until recently this antibiotic was kept in reserve for the treatment of staphylococcal infection resistant to benzylpenicillin, but, with more effective antibiotics now available, erythromycin can be used for more general purposes. Its main application is in adults or children suffering from an infection which would normally be treated with an oral penicillin, but in whom this is precluded because of hyper sensitivity. Erythromycin is very well tolerated and patients seldom become allergic to it. The dose is 250mg. by mouth every six hours. Oleandomycin, spiramycin and carbomycin are closely related but rather less potent antibiotics.
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