Meningococcal meningitis is treated with sulphonamides but other forms of meningitis due to penicillin sensitive infections (Pneumococcal, streptococcal) should be treated with bezylpenicillin by intrathecal and intramuscular injection for a period depending on the clinical response. Intrathecal administration may be required if penicillin given by other routes does not traverse the blood-brain barrier in adequate amounts, but the daily intrathecal dosage should not exceed 20,000 units if an irritant effect is to be avoided.
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