Unfortunately many strains of pathogenic staphylococci have emerged with a high degree of resistance to benzylpenicillin, especially in hospitals where this antibiotic is used freely. In every staphylococcal infection the possibility of the organism being resistant to benzylpenicillin must be considered and therefore its sensitivity should be determined by in vitro tests as soon as possible. If the staphylococcus proves to be resistant, the alternative antibiotics are methicillin, cloxacillin, erythromycin and fusidic acid the last two having the additional value of being suitable if the patient is hypersensitive to the penicillins.
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